Contents
17 May 2019
Vol 364, Issue 6441
Vol 364, Issue 6441
Contents
This Week in Science
Editorial
Editors' Choice
Products & Materials
- New Products
A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.
In Brief
In Depth
- Vanishing Bering Sea ice poses climate puzzle
For second winter in a row, ice cover shrinks to lowest levels seen in at least 4 decades.
- African swine fever marches across much of Asia
Rampant in China, the virus invades neighboring countries, threatening food security.
- European Commission kills billion-euro flagship concept
Six candidate research proposals lost in limbo.
- Facing Plan S, publishers may set papers free
Journals consider offering "green" open access from the time of publication.
- Climate scientists say no to flying
Limiting air travel to reduce carbon footprint works for some, but not all are on board.
Feature
- They persisted
In Michigan, concerned citizens have helped reveal contamination by long-lasting nonstick chemicals.
Working Life
Letters
Books et al.
- An exhibition fit for a king
Towering models, engaging interactives, and virtual reality bring the Tyrannosaurus rex to life
- Exploitation and extraction
A journalist reveals the human cost of modern mining through the vivid story of a young Bolivian mine worker
Policy Forum
- When science and politics collide: Enhancing the FDA
Science-based decisions on drug safety are threatened by political interference
Perspectives
- Putting sugars under strain
Adding strain to sugars enables synthesis of natural products and unusual oligosaccharides
- Absolute structure, at the nanoscale
The chirality of a tiny organic crystal is determined with electron diffraction
- Restoring tumor suppression
Restoring enzymatic activity of a tumor suppressor can prevent and treat cancer
- Curbing the costs of chemical manufacturing
Renewable feedstocks and fewer process steps can reduce financial and environmental costs
- Senolytic therapies for healthy longevity
Clearing senescent cells with targeted drugs could combat age-associated disease
Research Articles
- Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway
Lee et al. bolster a tumor suppressor as a potential cancer therapy.
- Local protein synthesis is a ubiquitous feature of neuronal pre- and postsynaptic compartments
Protein synthesis occurs in all synaptic compartments, including excitatory and inhibitory axon terminals.
- Hierarchical reasoning by neural circuits in the frontal cortex
Macaque monkeys are capable of hierarchical decision-making.
- Initial results from the New Horizons exploration of 2014 MU69, a small Kuiper Belt object
Initial results from the New Horizons flyby of Kuiper Belt object (486958) 2014 MU69, a contact binary, are presented.
- Identification of a regeneration-organizing cell in the Xenopus tail
Regeneration-organizing cells coordinate the regeneration of Xenopus tails after amputation.
- De novo design of tunable, pH-driven conformational changes
pH-driven conformational transitions with tunable cooperativity and pH set point are created using computational protein design.
Review
Reports
- Quantum gas microscopy of Rydberg macrodimers
Weakly bound molecules with bond lengths approaching a micrometer were characterized at high resolution in an optical lattice.
- Electron diffraction determines molecular absolute configuration in a pharmaceutical nanocrystal
Absolute stereochemistry in an organic crystal can be determined by electron diffraction despite limited crystal stability.
- Probing and imaging spin interactions with a magnetic single-molecule sensor
An inelastic tunneling probe images magnetic interactions between metal complexes at the atomic scale.
- Conformationally supple glucose monomers enable synthesis of the smallest cyclodextrins
Flexible monomers yield strained cyclic polymers of glucose with three or four units.
- Constrained sialic acid donors enable selective synthesis of α-glycosides
A removable linker enables α-glycosylation with sialic acid building blocks.
- Hydrodealkenylative C(sp3)–C(sp2) bond fragmentation
Cleavage of the bond between saturated and double-bonded carbons by ozone and iron can diversify abundant natural products.
- Single-cell genomics identifies cell type–specific molecular changes in autism
Single-cell analysis categorizes brain cell types most affected by autism and correlates transcriptional alterations with clinical symptoms.
- Mechanism of allosteric modulation of P-glycoprotein by transport substrates and inhibitors
Substrates and inhibitors differentially interact with an asymmetric post–ATP hydrolysis state of the P-glycoprotein drug transporter.
Erratum
From the AAAS Office of Publishing and Member Services
About The Cover
COVER The Kuiper Belt object 2014 MU69, as observed by the New Horizons spacecraft during a high-speed flyby on 1 January 2019. MU69 is found to be a two-lobed contact binary—formerly separate objects that have gently merged together. This enhanced-color image shows the uniform red color of both lobes, with brighter material at the contact point. See page eaaw9771.
Image: NASA/Roman Tkachenko
