An induced rebinding model of antigen discrimination

¹

,

²

,

³

et al. 2026

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…Optogenetic approaches provide a controlled platform for testing predictions of KPR models by isolating the contribution of binding duration to signaling output. These experiments align with a substantial body of work using altered peptide ligands and TCR mutants, which demonstrate that the T cell response depends strongly on the dwell-time of the TCR-pMHC interaction ( 58 , 61 ). Mathematical and computational studies further show how sequential signaling steps can amplify small differences in binding duration to produce robust antigen discrimination ( 75 – 77 ).…”

Section: Multi-scale Mechanisms For Recognizing Rates Of Stimulation

supporting

confidence: 76%

T cell decision-making decodes the dynamic antigenic landscape

¹

,

²

,

³

et al. 2026

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…Optogenetic approaches provide a controlled platform for testing predictions of KPR models by isolating the contribution of binding duration to signaling output. These experiments align with a substantial body of work using altered peptide ligands and TCR mutants, which demonstrate that the T cell response depends strongly on the dwell-time of the TCR-pMHC interaction ( 58 , 61 ). Mathematical and computational studies further show how sequential signaling steps can amplify small differences in binding duration to produce robust antigen discrimination ( 75 – 77 ).…”

Section: Multi-scale Mechanisms For Recognizing Rates Of Stimulation

supporting

confidence: 76%

TCR/pMHC Interaction: Phenotypic Model for an Unsolved Enigma

¹

,

²

,

García–Peñarrubia

³

2016

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…If t 0 is sufficiently large, this value of P T coincides with that obtained under steady-state conditions, i.e., by solving the equation δC T = 1 [see equation (1) in main text]. In the induced rebinding model, the above condition is

C_{N} MathClass-bin+ C_{N}^{MathClass-bin*} MathClass-rel= 1

(21). …”

Section: Mathematical Formulation Of the Model

supporting

confidence: 76%

The discriminatory power of the T cell receptor

Pettmann,

Huhn,

Abu Shah

et al. 2021

Elife

Self Cite

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…Although the KP mechanism can explain our discrimination data, it has been previously argued that it cannot simultaneously explain the observed high sensitivity of the TCR for antigen ( Altan-Bonnet and Germain, 2005 ; Dushek and Dushek and van der Merwe, 2014 ; Chakraborty and Weiss, 2014 ). We systematically varied the KP model parameters and determined whether discrimination and/or sensitivity were achieved for different levels of discrimination ( Figure 5G and H ).…”

Section: Results

mentioning

confidence: 53%

T cell decision-making decodes the dynamic antigenic landscape

¹

,

²

,

³

et al. 2026

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…Optogenetic approaches provide a controlled platform for testing predictions of KPR models by isolating the contribution of binding duration to signaling output. These experiments align with a substantial body of work using altered peptide ligands and TCR mutants, which demonstrate that the T cell response depends strongly on the dwell-time of the TCR-pMHC interaction ( 58 , 61 ). Mathematical and computational studies further show how sequential signaling steps can amplify small differences in binding duration to produce robust antigen discrimination ( 75 – 77 ).…”

Section: Multi-scale Mechanisms For Recognizing Rates Of Stimulation

supporting

confidence: 76%

TCR/pMHC Interaction: Phenotypic Model for an Unsolved Enigma

¹

,

²

,

García–Peñarrubia

³

2016

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…If t 0 is sufficiently large, this value of P T coincides with that obtained under steady-state conditions, i.e., by solving the equation δC T = 1 [see equation (1) in main text]. In the induced rebinding model, the above condition is

C_{N} MathClass-bin+ C_{N}^{MathClass-bin*} MathClass-rel= 1

(21). …”

Section: Mathematical Formulation Of the Model

supporting

confidence: 76%

The discriminatory power of the T cell receptor

Pettmann,

Huhn,

Abu Shah

et al. 2021

Elife

Self Cite

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…Although the KP mechanism can explain our discrimination data, it has been previously argued that it cannot simultaneously explain the observed high sensitivity of the TCR for antigen ( Altan-Bonnet and Germain, 2005 ; Dushek and Dushek and van der Merwe, 2014 ; Chakraborty and Weiss, 2014 ). We systematically varied the KP model parameters and determined whether discrimination and/or sensitivity were achieved for different levels of discrimination ( Figure 5G and H ).…”

Section: Results

mentioning

confidence: 53%

T cell decision-making decodes the dynamic antigenic landscape

¹

,

²

,

³

et al. 2026

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…Optogenetic approaches provide a controlled platform for testing predictions of KPR models by isolating the contribution of binding duration to signaling output. These experiments align with a substantial body of work using altered peptide ligands and TCR mutants, which demonstrate that the T cell response depends strongly on the dwell-time of the TCR-pMHC interaction ( 58 , 61 ). Mathematical and computational studies further show how sequential signaling steps can amplify small differences in binding duration to produce robust antigen discrimination ( 75 – 77 ).…”

Section: Multi-scale Mechanisms For Recognizing Rates Of Stimulation

supporting

confidence: 76%

TCR/pMHC Interaction: Phenotypic Model for an Unsolved Enigma

¹

,

²

,

García–Peñarrubia

³

2016

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…If t 0 is sufficiently large, this value of P T coincides with that obtained under steady-state conditions, i.e., by solving the equation δC T = 1 [see equation (1) in main text]. In the induced rebinding model, the above condition is

C_{N} MathClass-bin+ C_{N}^{MathClass-bin*} MathClass-rel= 1

(21). …”

Section: Mathematical Formulation Of the Model

supporting

confidence: 76%

The discriminatory power of the T cell receptor

Pettmann,

Huhn,

Abu Shah

et al. 2021

Elife

Self Cite

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…Although the KP mechanism can explain our discrimination data, it has been previously argued that it cannot simultaneously explain the observed high sensitivity of the TCR for antigen ( Altan-Bonnet and Germain, 2005 ; Dushek and Dushek and van der Merwe, 2014 ; Chakraborty and Weiss, 2014 ). We systematically varied the KP model parameters and determined whether discrimination and/or sensitivity were achieved for different levels of discrimination ( Figure 5G and H ).…”

Section: Results

mentioning

confidence: 53%