Molecular developmental mechanism in polypterid fish provides insight into the origin of vertebrate lungs

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,

²

,

³

et al. 2021

Cell

Smart CitationsHow this paper cites the one you are viewing

“…These include two well-known lung development genes (Tbx4 and Tbx5) that were apparently present in the common ancestor of cartilaginous and bony fishes. It is also consistent with a previous report on an important lung-related regulatory enhancer (lung mesenchyme-specific enhancer, LME) of Tbx4, which is present in cartilaginous fishes and also exists in the bichir, bowfin, and spotted gar (Hara et al, 2018;Tatsumi et al, 2016) (Figure S5D). In situ hybridization experiments with five of these genes confirmed that they are all highly active in alveolar cells of both the mouse and the bichir but weakly expressed in the swim bladder surface of the zebrafish (Figure 5F).…”

Section: Transcriptional Profiles Reveal the Evolution Of Vertebrate ...

supporting

confidence: 93%

Tracing the genetic footprints of vertebrate landing in non-teleost ray-finned fishes

¹

,

²

,

³

et al. 2021

Cell

Smart CitationsHow this paper cites the one you are viewing

“…These include two well-known lung development genes (Tbx4 and Tbx5) that were apparently present in the common ancestor of cartilaginous and bony fishes. It is also consistent with a previous report on an important lung-related regulatory enhancer (lung mesenchyme-specific enhancer, LME) of Tbx4, which is present in cartilaginous fishes and also exists in the bichir, bowfin, and spotted gar (Hara et al, 2018;Tatsumi et al, 2016) (Figure S5D). In situ hybridization experiments with five of these genes confirmed that they are all highly active in alveolar cells of both the mouse and the bichir but weakly expressed in the swim bladder surface of the zebrafish (Figure 5F).…”

Section: Transcriptional Profiles Reveal the Evolution Of Vertebrate ...

supporting

confidence: 93%

Proc. Natl. Acad. Sci. U.S.A.

Evolutionarily conserved Tbx5 – Wnt2/2b pathway orchestrates cardiopulmonary development

Steimle

¹

,

Rankin

²

,

Slagle

³

et al. 2018

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…Overall, our work suggests a fundamental role for Tbx5 in tetrapod lung development and the possibility that the evolutionary origin of lungs may have involved the recruitment of TBX5 from an ancestral cardiac expression domain. Although a recent model suggested that the lungs and SB are evolutionarily derived from a common structure, we find that tbx5 is not required for the development of both (43,44). Previous work in zebrafish demonstrates that depletion of wnt2 and wnt2bb causes SB agenesis, similar to their requirement in lung specification (17,38).…”

Section: Discussion

contrasting

confidence: 58%

Evolution and Development

Changes in Nkx2.1, Sox2, Bmp4, and Bmp16 expression underlying the lung‐to‐gas bladder evolutionary transition in ray‐finned fishes

Funk

¹

,

Breen

²

,

Sanketi

³

et al. 2020

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…In addition, we find Nkx2.1 to be expressed during early lung development in bichir, right after initial budding (Stage 34). Our results show an earlier expression of Nkx2.1 than found by Tatsumi et al (2016), who observed Nkx2.1 be weakly expressed throughout the bichir foregut and in the lungs no earlier than 12 dpf. Bmp16 is expressed strongly in the anterior gas bladder (GB); however, more posteriorly, where the gas bladder expands laterally, Bmp16 expression is absent.…”

Section: Conserved Gene Expression Patterns Between Bichir and Tetr

supporting

confidence: 59%

Tracing the genetic footprints of vertebrate landing in non-teleost ray-finned fishes

¹

,

²

,

³

et al. 2021

Cell

Smart CitationsHow this paper cites the one you are viewing

“…These include two well-known lung development genes (Tbx4 and Tbx5) that were apparently present in the common ancestor of cartilaginous and bony fishes. It is also consistent with a previous report on an important lung-related regulatory enhancer (lung mesenchyme-specific enhancer, LME) of Tbx4, which is present in cartilaginous fishes and also exists in the bichir, bowfin, and spotted gar (Hara et al, 2018;Tatsumi et al, 2016) (Figure S5D). In situ hybridization experiments with five of these genes confirmed that they are all highly active in alveolar cells of both the mouse and the bichir but weakly expressed in the swim bladder surface of the zebrafish (Figure 5F).…”

Section: Transcriptional Profiles Reveal the Evolution Of Vertebrate ...

supporting

confidence: 93%

Proc. Natl. Acad. Sci. U.S.A.

Evolutionarily conserved Tbx5 – Wnt2/2b pathway orchestrates cardiopulmonary development

Steimle

¹

,

Rankin

²

,

Slagle

³

et al. 2018

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…Overall, our work suggests a fundamental role for Tbx5 in tetrapod lung development and the possibility that the evolutionary origin of lungs may have involved the recruitment of TBX5 from an ancestral cardiac expression domain. Although a recent model suggested that the lungs and SB are evolutionarily derived from a common structure, we find that tbx5 is not required for the development of both (43,44). Previous work in zebrafish demonstrates that depletion of wnt2 and wnt2bb causes SB agenesis, similar to their requirement in lung specification (17,38).…”

Section: Discussion

contrasting

confidence: 58%

Evolution and Development

Changes in Nkx2.1, Sox2, Bmp4, and Bmp16 expression underlying the lung‐to‐gas bladder evolutionary transition in ray‐finned fishes

Funk

¹

,

Breen

²

,

Sanketi

³

et al. 2020

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…In addition, we find Nkx2.1 to be expressed during early lung development in bichir, right after initial budding (Stage 34). Our results show an earlier expression of Nkx2.1 than found by Tatsumi et al (2016), who observed Nkx2.1 be weakly expressed throughout the bichir foregut and in the lungs no earlier than 12 dpf. Bmp16 is expressed strongly in the anterior gas bladder (GB); however, more posteriorly, where the gas bladder expands laterally, Bmp16 expression is absent.…”

Section: Conserved Gene Expression Patterns Between Bichir and Tetr

supporting

confidence: 59%

Tracing the genetic footprints of vertebrate landing in non-teleost ray-finned fishes

¹

,

²

,

³

et al. 2021

Cell

Smart CitationsHow this paper cites the one you are viewing

“…These include two well-known lung development genes (Tbx4 and Tbx5) that were apparently present in the common ancestor of cartilaginous and bony fishes. It is also consistent with a previous report on an important lung-related regulatory enhancer (lung mesenchyme-specific enhancer, LME) of Tbx4, which is present in cartilaginous fishes and also exists in the bichir, bowfin, and spotted gar (Hara et al, 2018;Tatsumi et al, 2016) (Figure S5D). In situ hybridization experiments with five of these genes confirmed that they are all highly active in alveolar cells of both the mouse and the bichir but weakly expressed in the swim bladder surface of the zebrafish (Figure 5F).…”

Section: Transcriptional Profiles Reveal the Evolution Of Vertebrate ...

supporting

confidence: 93%

Proc. Natl. Acad. Sci. U.S.A.

Evolutionarily conserved Tbx5 – Wnt2/2b pathway orchestrates cardiopulmonary development

Steimle

¹

,

Rankin

²

,

Slagle

³

et al. 2018

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…Overall, our work suggests a fundamental role for Tbx5 in tetrapod lung development and the possibility that the evolutionary origin of lungs may have involved the recruitment of TBX5 from an ancestral cardiac expression domain. Although a recent model suggested that the lungs and SB are evolutionarily derived from a common structure, we find that tbx5 is not required for the development of both (43,44). Previous work in zebrafish demonstrates that depletion of wnt2 and wnt2bb causes SB agenesis, similar to their requirement in lung specification (17,38).…”

Section: Discussion

contrasting

confidence: 58%

Evolution and Development

Changes in Nkx2.1, Sox2, Bmp4, and Bmp16 expression underlying the lung‐to‐gas bladder evolutionary transition in ray‐finned fishes

Funk

¹

,

Breen

²

,

Sanketi

³

et al. 2020

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…In addition, we find Nkx2.1 to be expressed during early lung development in bichir, right after initial budding (Stage 34). Our results show an earlier expression of Nkx2.1 than found by Tatsumi et al (2016), who observed Nkx2.1 be weakly expressed throughout the bichir foregut and in the lungs no earlier than 12 dpf. Bmp16 is expressed strongly in the anterior gas bladder (GB); however, more posteriorly, where the gas bladder expands laterally, Bmp16 expression is absent.…”

Section: Conserved Gene Expression Patterns Between Bichir and Tetr

supporting

confidence: 59%