close
Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2001 Dec;8(6):1163-74.
doi: 10.1016/s1097-2765(01)00419-1.

Recombination at double-strand breaks and DNA ends: conserved mechanisms from phage to humans

G A Cromie  1 , J C Connelly, D R Leach
Affiliations
Free article
Review

Recombination at double-strand breaks and DNA ends: conserved mechanisms from phage to humans

G A Cromie et al. Mol Cell. 2001 Dec.
Free article

Abstract

The recombination mechanisms that deal with double-strand breaks in organisms as diverse as phage, bacteria, yeast, and humans are remarkably conserved. We discuss conservation in the biochemical pathways required to recombine DNA ends and in the structure of the DNA products. In addition, we highlight that two fundamentally distinct broken DNA substrates exist and describe how they are repaired differently by recombination. Finally, we discuss the need to coordinate recombinational repair with cell division through DNA damage response pathways.

PubMed Disclaimer

Publication types

LinkOut - more resources