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. 2009 Dec 9;27(52):7385-93.
doi: 10.1016/j.vaccine.2009.09.021. Epub 2009 Sep 18.

Influenza recombinant vaccine: matrix protein M1 on the platform of the adenovirus dodecahedron

A Naskalska  1 , E Szolajska, L Chaperot, J Angel, J Plumas, J Chroboczek
Affiliations

Influenza recombinant vaccine: matrix protein M1 on the platform of the adenovirus dodecahedron

A Naskalska et al. Vaccine. .

Abstract

We propose a novel influenza vaccine composed of the adenovirus dodecahedron (Dd) as delivery platform carrying an internal influenza matrix protein M1. To attach the antigen to the vector we used WW domains interacting with Dd. Successful internalization of the Dd-M1WW complex was observed using biochemical and cell biology techniques. We show here that the complex of Dd with antigen is a potent activator of human myeloid dendritic cells (MDC), and that it is efficiently presented by MDC to M1-specific CD8+ T lymphocytes. These results show that proposed vaccine model is feasible and that adenovirus dodecahedron is a potent delivery platform for foreign antigens to human cells.

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