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Review
. 2018 May;8(5):239.
doi: 10.1007/s13205-018-1246-7. Epub 2018 May 4.

DNA as a digital information storage device: hope or hype?

Affiliations
Review

DNA as a digital information storage device: hope or hype?

Darshan Panda et al. 3 Biotech. 2018 May.

Abstract

The total digital information today amounts to 3.52 × 1022 bits globally, and at its consistent exponential rate of growth is expected to reach 3 × 1024 bits by 2040. Data storage density of silicon chips is limited, and magnetic tapes used to maintain large-scale permanent archives begin to deteriorate within 20 years. Since silicon has limited data storage ability and serious limitations, such as human health hazards and environmental pollution, researchers across the world are intently searching for an appropriate alternative. Deoxyribonucleic acid (DNA) is an appealing option for such a purpose due to its endurance, a higher degree of compaction, and similarity to the sequential code of 0's and 1's as found in a computer. This emerging field of DNA as means of data storage has the potential to transform science fiction into reality, wherein a device that can fit in our palms can accommodate the information of the entire world, as latest research has revealed that just four grams of DNA could store the annual global digital information. DNA has all the properties to supersede the conventional hard disk, as it is capable of retaining ten times more data, has a thousandfold storage density, and consumes 108 times less power to store a similar amount of data. Although DNA has an enormous potential as a data storage device of the future, multiple bottlenecks such as exorbitant costs, excruciatingly slow writing and reading mechanisms, and vulnerability to mutations or errors need to be resolved. In this review, we have critically analyzed the emergence of DNA as a molecular storage device for the future, its ability to address the future digital data crunch, potential challenges in achieving this objective, various current industrial initiatives, and major breakthroughs.

Keywords: DNA hard drive; DNA steganography; DNA storage; Data crunch; Data longevity; Digital data; Silicone pollution.

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Conflict of interest statement

Compliance with ethical standardsThe authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Microvenus icon coding in synthetic DNA by Joe Davis
Fig. 2
Fig. 2
The encoding scheme developed by Clelland et al. The scheme involved encryption of letters in DNA bases, encoding by synthesis of DNA, PCR amplification using specific primer pair, sequencing of the amplified product followed by decoding on the basis of primary encryption
Fig. 3
Fig. 3
DNA digital data storage: turning warehouse-sized storage to one-micrometer block of molecules (steps involved in using DNA as digital data storage)
Fig. 4
Fig. 4
A timeline of data storage in the nucleic acid. NPC Netherlands Proteomics Centre, NGI Netherlands genomics initiative. Full citations are available in the reference section

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