Dynamic light application therapy to reduce the incidence and duration of delirium in intensive-care patients: a randomised controlled trial

Simons, Koen S.; Laheij, Robert J.F.; Boogaard, Mark van den; Moviat, Miriam; Paling, Anne J; Polderman, Florens N; Rozendaal, Frans W.; Salet, Geertruda A M; Hoeven, Johannes G. van der; Pickkers, Peter; Jager, Cornelis P. C. de

doi:10.1016/s2213-2600(16)00025-4

The Lancet Respiratory Medicine

2016

DOI: 10.1016/s2213-2600(16)00025-4

|Get access via publisher |Summarize |Cite

|

Sign up to set email alerts

Dynamic light application therapy to reduce the incidence and duration of delirium in intensive-care patients: a randomised controlled trial

Koen S. Simons

¹

,

Robert J.F. Laheij

²

,

Mark van den Boogaard

³

et al.

Help me understand this report

Cited by 115 publications

(145 citation statements)

References 32 publications

Supporting

2

Mentioning

135

Contrasting

2

Unclassified

6

Order By: Relevance

“…Our study results revealed different circadian melatonin patterns between patients in both groups, attributable to distinct photometric parameters of the DLS and the FT-CL. These findings contrast previous results from a randomized controlled trial (RCT), which showed no effect of bright-light therapy on ICU delirium ( 43 ). In this RCT, the DLS emitted up to 800 lux from a relatively small area, possibly increasing glare-related effects and potentially contributing to the onset of delirium.…”

Section: Discussion

contrasting

confidence: 99%

Modification in ICU Design May Affect Delirium and Circadian Melatonin: A Proof of Concept Pilot Study

Spies

¹

,

Piazena

²

,

Deja

³

et al. 2023

Critical Care Medicine

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…Our study results revealed different circadian melatonin patterns between patients in both groups, attributable to distinct photometric parameters of the DLS and the FT-CL. These findings contrast previous results from a randomized controlled trial (RCT), which showed no effect of bright-light therapy on ICU delirium ( 43 ). In this RCT, the DLS emitted up to 800 lux from a relatively small area, possibly increasing glare-related effects and potentially contributing to the onset of delirium.…”

Section: Discussion

contrasting

confidence: 99%

Modification in ICU Design May Affect Delirium and Circadian Melatonin: A Proof of Concept Pilot Study

Spies

¹

,

Piazena

²

,

Deja

³

et al. 2023

Critical Care Medicine

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…These excluded patients had significantly higher mortality (data not shown), and if included, total mortality would have been 19%. Our results are comparable to those of the annual Danish intensive care report and also to the Dutch light trial presenting a mortality of 12–14% …”

Section: Discussion

supporting

confidence: 88%

“…Our results regarding light therapy are comparable to a recent randomized Dutch trial that examined the effect of dynamic light exposure in an ICU setting. The trial included 743 patients and found an insignificant 3% reduction in incidence of delirium with circadian light.…”

Section: Discussion

supporting

confidence: 81%

“…A study from 2013 found that 65% of patients had CAM‐ICU‐positive delirium at three Danish ICUs. The Dutch dynamic light study found a delirium incidence of 35% . The population in these studies differs from ours with regard to age, disease severity, and inclusion and exclusion criteria.…”

Section: Discussion

contrasting

confidence: 70%

See 1 more Smart Citation

Delirium and effect of circadian light in the intensive care unit: a retrospective cohort study

Estrup

¹

,

Kjer

²

,

Poulsen

³

et al. 2017

Acta Anaesthesiol Scand

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…The maximum illuminance was 1700 lx in the study of Simons et al. (2016), and illuminance was above 2500 lx in other studies (Ono et al. 2011; Taguchi, Yano, and Kido 2007; Van den Bussche et al.…”

Section: Discussion

mentioning

confidence: 69%

Effects of Sensory‐Based Interventions on Delirium Prevention in Critically Ill Patients: A Systematic Review and Meta‐Analysis

Xu

¹

,

Zhang

²

,

Yuan

³

et al. 2025

Int J of Nursing Practice

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

Scite is an AI-powered platform that helps researchers discover and evaluate scientific literature through Smart Citations, showing whether studies support or contradict a claim. Now part of Research Solutions, Scite has indexed 1.6B+ citations, partners with 30+ publishers, and serves 2M users worldwide.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA