Seizure cluster: Definition, prevalence, consequences, and management

“…When examining the pattern of SWDs in D2J Scn2a gt/gt mice during 24-hour analysis, we observed that these epileptiform events tend to cluster instead of being evenly distributed, a trait frequently reported in human seizure patients (42) ( Supplemental Figure 3A ). Additionally, repeated trains of short SWDs that spread across several minutes were also frequently observed in the D2J Scn2a gt/gt mice ( Supplemental Figure 3B ).…”

“…At the initial presentation, 68% of the cohort had clustered seizures which must be a red flag for both clinicians and families, as it is often considered indicative of poorly controlled or drug-resistant epilepsy. 10 Also, clusters of seizures becomes one of the most unforgettable moments in the lifetime of the family In comparisons between the cluster (n = 47) and non-cluster (n = 23) groups, the age at first seizure was found to be significantly earlier in the cluster group (6.3 ± 2.97 months vs. 8.3 ± 4.53 months; p = .037). In contrast, no statistically significant differences were observed between the two groups regarding the age at last seizure (9.5 ± 4.84 months vs. 11.8 ± 7.5 months; p = .511) or the latency between treatment initiation and seizure cessation (1.1 ± 2.5 months vs. 1.0 ± 1.9 months; p = .944).…”

“…CT is a diagnostic imaging technique that creates detailed images of the body’s internal structures using a combination of computer technology and x‐rays [ 59 ]. Compared to conventional x‐rays, CT scans provide more precise imaging of bones, muscles, fat, organs, and blood vessels.…”