Norquetiapine

Norquetiapine
Clinical data
Other names	N-Desalkylquetiapine; NQTP
Drug class	Atypical antipsychotic
ATC code	N05AH02 (WHO) ;
Identifiers
	IUPAC name 6-piperazin-1-ylbenzo[b][1,4]benzothiazepine;
CAS Number	5747-48-8 [5747-48-8];
PubChem CID	11369918;
IUPHAR/BPS	7545;
ChemSpider	9544835 ;
UNII	V3H1ZVV9S6;
ChEBI	CHEBI:188278 ;
ChEMBL	ChEMBL3526391 ;
CompTox Dashboard (EPA)	DTXSID30881147 ;
ECHA InfoCard	100.118.138
Chemical and physical data
Formula	C17H17N3S
Molar mass	295.40 g·mol−1
3D model (JSmol)	Interactive image;
Boiling point	465.2 °C (869.4 °F) ±55.0 °C at 760 mmHg
	SMILES C1CN(CCN1)C2=NC3=CC=CC=C3SC4=CC=CC=C42;
	InChI InChI=1S/C17H17N3S/c1-3-7-15-13(5-1)17(20-11-9-18-10-12-20)19-14-6-2-4-8-16(14)21-15/h1-8,18H,9-12H2; Key:JLOAJISUHPIQOX-UHFFFAOYSA-N;
	(verify)

References

↑ "CAS Common Chemistry". commonchemistry.cas.org. Archived from the original on 2025-08-12. Retrieved 2026-07-07.
↑ Jensen NH, Rodriguiz RM, Caron MG, Wetsel WC, Rothman RB, Roth BL (September 2008). "N-desalkylquetiapine, a potent norepinephrine reuptake inhibitor and partial 5-HT1A agonist, as a putative mediator of quetiapine's antidepressant activity". Neuropsychopharmacology. 33 (10): 2303–2312. doi:10.1038/SJ.NPP.1301646. PMID 18059438.
↑ Di Benedetto B, Kühn R, Nothdurfter C, Rein T, Wurst W, Rupprecht R (January 2012). "N-desalkylquetiapine activates ERK1/2 to induce GDNF release in C6 glioma cells: a putative cellular mechanism for quetiapine as antidepressant". Neuropharmacology. 62 (1): 209–216. doi:10.1016/j.neuropharm.2011.07.001. PMID 21767553.
↑ Brunton L, Chabner B, Knollman B (2010). Goodman and Gilman's The Pharmacological Basis of Therapeutics (12th ed.). McGraw Hill Professional. ISBN 978-0-07-162442-8.
↑ PubChem. "Quetiapine". Pubchem.ncbi.NLM.nih.gov. Retrieved 2026-07-07.
↑ "Norquetiapine". ChemSpider.com. Retrieved 2026-07-07.

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