Troponin C

Cardiac sarcomere structure, featuring troponin C

Troponin

Troponin C (TN-C or TnC) is a protein which is part of the troponin complex. There are two versions (paralogs) in humans. It contains four calcium-binding EF hands, although different isoforms may have fewer than four functional calcium-binding subdomains. It is a component of thin filaments, along with actin and tropomyosin. It contains an N lobe and a C lobe. The C lobe serves a structural purpose and binds to the N domain of troponin I (TnI). The C lobe can bind either Ca²⁺ or Mg²⁺. The N lobe, which binds only Ca²⁺, is the regulatory lobe and binds to the C domain of troponin I after calcium binding.

TnC is structurally similar to calmodulin and myosin light chain. These three groups of proteins form a family.

Isoforms

Troponin C, slow skeletal and cardiac muscles
Identifiers
Symbol	TNNC1
HGNC	11943
OMIM	191040
RefSeq	NM_003280
UniProt	P63316
Other data
Locus	Chr. 3 p21.1
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Troponin C, skeletal muscle
Identifiers
Symbol	TNNC2
HGNC	11944
OMIM	191039
RefSeq	NP_003270.1
UniProt	P02585
Other data
Locus	Chr. 20 q13.12
Search for Structures Swiss-model Domains InterPro

The tissue specific subtypes are:

• Slow troponin C, TNNC1 (3p21.1 Online Mendelian Inheritance in Man (OMIM): 191040)
• Fast troponin C, TNNC2 (20q12-q13.11, Online Mendelian Inheritance in Man (OMIM): 191039)

See also

• Troponin
• Troponin T
• Troponin I
• Calcium-binding protein
• Sliding filament model

External links

• Troponin+C at the U.S. National Library of Medicine Medical Subject Headings (MeSH)