ADGRF1

ADGRF1
Identifiers
Aliases	ADGRF1, KPG_012, PGR19, hGPCR36, GPR110, adhesion G protein-coupled receptor F1
External IDs	OMIM: 617430; MGI: 1924846; GeneCards: ADGRF1
Gene location (Human)
Chr.	Chromosome 6 (human)
End	47,042,350 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	43,635,628 bp
RNA expression pattern
	Top expressed in
	palpebral conjunctiva; ; amniotic fluid; ; epithelium of nasopharynx; ; olfactory zone of nasal mucosa; ; buccal mucosa cell; ; bronchial epithelial cell; ; renal medulla; ; right lobe of thyroid gland; ; gallbladder; ; oral cavity;
	Top expressed in
	conjunctival fornix; ; cornea; ; right kidney; ; liver; ; duodenum; ; human kidney; ; colon; ; renal cortex; ; muscle of thigh; ; hypothalamus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; transmembrane signaling receptor activity; signal transducer activity;
Cellular component	integral component of membrane; extracellular region; plasma membrane; membrane; intracellular anatomical structure;
Biological process	G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; signal transduction; synapse assembly; memory; neuron projection development; positive regulation of CREB transcription factor activity; adenylate cyclase-activating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	266977
	77596
	ENSG00000153292
	ENSMUSG00000041293
	Q5T601
	Q8VEC3
	NM_025048; NM_153840
	NM_133776
	NP_079324; NP_722582
	NP_598537
	Wikidata
View/Edit Human	View/Edit Mouse

Adhesion G protein-coupled receptor F1 is a protein that in humans is encoded by the ADGRF1 gene (previously GPR110).^[5]^[6] This protein acts as a receptor for synaptamide, an omega-3 fatty acid found significantly in the brain.^[7] It is a G protein-coupled receptor which couples to Gs alpha subunit G-proteins (and potentially others).^[7]

The ADGRF1 protein is a member of the adhesion-GPCR receptor family, which is a subfamily of G protein coupled receptors.^[8] Family members are characterized by an extended extracellular region with a variable number of N-terminal protein modules coupled to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.^[9]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000153292 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041293 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Lett. 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. S2CID 7449692.
↑ "Entrez Gene: GPR110 G protein-coupled receptor 110".
1 2 "Adhesion G protein-coupled receptor F1". uniprot.org. UniProt consortium. Retrieved 2026-08-23.
↑ Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.
↑ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". EMBO J. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Takeda S, Kadowaki S, Haga T, et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878. S2CID 7116392.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Vassilatis DK, Hohmann JG, Zeng H, et al. (2003). "The G protein-coupled receptor repertoires of human and mouse". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4903–8. Bibcode:2003PNAS..100.4903V. doi:10.1073/pnas.0230374100. PMC 153653. PMID 12679517.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000153292 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041293 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12435584-5] Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Lett. 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. S2CID 7449692.

[entrez-6] "Entrez Gene: GPR110 G protein-coupled receptor 110".

[uniprot-7] 1 2 "Adhesion G protein-coupled receptor F1". uniprot.org. UniProt consortium. Retrieved 2026-08-23.

[isbn1-4419-7912-3-8] Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.

[pmid22333914-9] Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". EMBO J. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.

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References

Further reading