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ADGRF3

From Wikipedia, the free encyclopedia

ADGRF3
Identifiers
AliasesADGRF3, PGR23, hGPCR37, GPR113, adhesion G protein-coupled receptor F3
External IDsMGI: 2685887; GeneCards: ADGRF3
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

165082

381628

Ensembl

ENSG00000173567

ENSMUSG00000067642

UniProt

Q8IZF5

Q58Y75

RefSeq (mRNA)

NM_001014394

RefSeq (protein)

NP_001138640
NP_001138641
NP_001308900
NP_001308904
NP_722577

NP_001014416

Location (UCSC)Chr 2: 26.31 – 26.35 MbChr 5: 30.4 – 30.41 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Adhesion G protein-coupled receptor F3 is a protein that in humans is encoded by the gene ADGRF3 (previously GPR113).[5][6] The ADGRF3 protein is an orphan receptor that is part of the adhesion subfamily of G protein-coupled receptor.[7]

Gene

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The human GPR113 gene is located on chromosome 2 (2p23.3). This gene spans the length of a 38.65kb region from base 26531041 to 26569685 on the negative strand.[8] The GPR113 gene has two neighbors on either side on the negative strand: OTOF otoferlin preceding and HADHA hydroxyacyl-CoA following. Directly opposite the GPR113 on the positive strand is the EPT1 gene. The GPR113 gene is also known by the aliases PGR23 and HGPCR37.[9]

Evolution

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The GPR113 has 5 human paralogs GPR110, GPR115, GPR128, GPR111, and GPR116.[9] GPR113 is well conserved in mammals from primates to semi-aquatic species, as well as some amphibians. These include the Common Chimpanzee, the African Bush Elephant, the Platypus, and the Western Clawed Frog.[10] Homologous domains that are well conserved throughout orthologs center in the 7 transmembrane receptor (Secretin family) region highlighted in purple in the figure.[11]

Protein

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Annotated primary structure of the GPR113 Protein

The protein product of GPR113 gene is a G-protein coupled receptor. The protein has three transcript variants in humans.[12] Of these three, GPR113 Variant 1 has the longest amino acid sequence, and has the highest identity to orthologs. This leads to the conclusion that GPR113 Variant 1 is the homo sapiens descendant of the ancestral GPR113 gene. GPR113 Var 1 contains 1079 Amino Acids, and is integral to the plasma membrane.[13] The 7-pass receptor contains 4 domains highlighted in the figure at right: Signal Peptide (Red), Hormone Receptor Domain (Blue), Latrophilin/CL-1-like GPS domain (Orange), and the 7-transmembrane receptor (Purple). Between the Hormone Receptor Domain and the GPS is a Domain of unknown function that is not highlighted.

Clinical significance

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The clinical significance of this protein has not been established, but GPR113 has been found to be expressed differentially under diseased conditions. Under the condition of Type 2 diabetes, the percentile rank relative to other transcripts decreases relative to normal cell function.[14] The deletion of TP63, which mediates a wide variety of important body processes, also produces decreased GPR113 expression.[15] In mice brains, the cerebellum and the olfactory bulb both show transcription of the GPR113 gene.[16] Additionally, a study from the National Institute of Deafness and Other Communication Disorders has identified GPR113 expression to be highly restricted to a subset of taste receptor cells.[17] This paper's conclusions, coupled with olfactory bulb expression levels, could provide an avenue for future research, potentially illuminating more about GPR113's function.

References

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  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000173567 – Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000067642 – Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB (November 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Letters. 531 (3): 407–414. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. S2CID 7449692.
  6. ↑ "Entrez Gene: GPR113 G protein-coupled receptor 113".
  7. ↑ "Q8IZF5 · AGRF3_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-23.
  8. ↑ "Homo sapiens chromosome 2, GRCh37.p13 Primary Assembly". Nucleotide. U.S. National Library of Medicine. 2013-08-13.
  9. 1 2 "ADGRF3 Gene - GeneCards | AGRF3 Protein | AGRF3 Antibody".
  10. ↑ "BLAST: Basic Local Alignment Search Tool".
  11. ↑ "SDSC Biology Workbench".
  12. ↑ "Homo sapiens adhesion G protein-coupled receptor F3 (ADGRF3), transcript variant 2, mRNA". Nucleotide. U.S. National Library of Medicine. 2018-06-24.
  13. ↑ "ADGRF3 - Adhesion G-protein coupled receptor F3 precursor - Homo sapiens (Human) - ADGRF3 gene & protein".
  14. ↑ "ADGRF3 - Type 2 diabetes and role of hepatokines". GEO Profiles. U.S. National Center for Biotechnology Information (NCBI). 71224040.
  15. ↑ "ADGRF3 - p63 depletion effect". GEO Profiles. U.S. National Center for Biotechnology Information (NCBI). 34655140.
  16. ↑ "G protein-coupled receptor 113". Allen Brain Atlas: Mouse Brain.
  17. ↑ LopezJimenez ND, Sainz E, Cavenagh MM, Cruz-Ithier MA, Blackwood CA, Battey JF, et al. (April 2005). "Two novel genes, Gpr113, which encodes a family 2 G-protein-coupled receptor, and Trcg1, are selectively expressed in taste receptor cells". Genomics. 85 (4): 472–482. doi:10.1016/j.ygeno.2004.12.005. PMID 15780750.

Further reading

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